Publications

Atlas-guided discovery of transcription factors for T cell programming

Chung HK, Liu C, Battu A, … McDonald B, … Milner JJ, Kaech SM, Wang W

Nature 2026 651(8107):1077–1087

Nutrient-driven histone code determines exhausted CD8⁺ T cell fates

Ma S, Dahabieh MS, Mann TH, Zhao S, McDonald B, … Jones RG, Kaech SM

Science 2025 387(6734):eadj3020

Late-rising CD4 T cells resolve mouse cytomegalovirus persistent replication in the salivary gland

Brunel S, Picarda G, Gupta A, Ghosh R, McDonald B, … Vijayanand P, Benedict CA

PLoS Pathogens 2024 20(1):e1011852

Early chromatin remodeling events in acutely stimulated CD8⁺ T cells

McDonald B, Chick BY, Hargreaves DC, Kaech SM

Yale Journal of Biology and Medicine 2023 96(4):467–473

CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma

Chen D, Varanasi SK, Hara T, Traina K, Sun M, McDonald B, … Hunter T, Lemke G, Kaech SM

Immunity 2023 56(9):2086–2104.e8

Canonical BAF complex activity shapes the enhancer landscape that licenses CD8⁺ T cell effector and memory fates

McDonald B, Chick BY, Ahmed NS, Burns M, Ma S, Casillas E, Chen D, Mann TH, O'Connor C, Hah N, Hargreaves DC, Kaech SM

Immunity 2023 56(6):1303–1319.e5

SMAD4 and TGFβ are architects of inverse genetic programs during fate determination of antiviral CTLs

Chandiran K, Suarez-Ramirez JE, Hu Y, Jellison ER, Ugur Z, Low JS, McDonald B, Kaech SM, Cauley LS

eLife 2022 11:e76457

Motility matters: how CD8⁺ T-cell trafficking influences effector and memory cell differentiation

Farsakoglu Y, McDonald B, Kaech SM

Cold Spring Harbor Perspectives in Biology 2021 13(8):a038075 Review

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8⁺ T cells in tumors

Xu S, Chaudhary O, Rodríguez-Morales P, … McDonald B, … Emu B, Cui G, Kaech SM

Immunity 2021 54(7):1561–1577.e7

Fc-optimized anti-CCR8 antibody depletes regulatory T cells in human tumor models

Campbell JR*, McDonald BR*, Mesko PB, Siemers NO, Singh PB, … Jain R, Lan RY

Cancer Research 2021 81(11):2983–2994 * Co-first authors

The architectural design of CD8⁺ T cell responses in acute and chronic infection: parallel structures with divergent fates

Chung HK, McDonald B, Kaech SM

Journal of Experimental Medicine 2021 218(4):e20201730 Review

Heterogenous populations of tissue-resident CD8⁺ T cells are generated in response to infection and malignancy

Milner JJ, Toma C, He Z, Kurd NS, Nguyen QP, McDonald B, … Chang JT, Omilusik KD, Goldrath AW

Immunity 2020 52(5):808–824.e7

Cytomegalovirus evades TRAIL-mediated innate lymphoid cell 1 defenses

Picarda G, Ghosh R, McDonald B, Verma S, Thiault N, El Morabiti R, Griffith TS, Benedict CA

Journal of Virology 2019 93(16):e00617-19

cGAS-STING signaling regulates initial innate control of cytomegalovirus infection

Lio CW, McDonald B, Takahashi M, Dhanwani R, Sharma N, Huang J, Pham E, Benedict CA, Sharma S

Journal of Virology 2016 90(17):7789–7797

Cytomegalovirus-specific CD4 T cells are cytolytic and mediate vaccine protection

Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, Benedict CA

Journal of Virology 2016 90(2):650–658

Cardif (MAVS) regulates the maturation of NK cells

Haynes LD, Verma S, McDonald B, Wu R, Tacke R, Nowyhed HN, Ekstein J, Feuvrier A, Benedict CA, Hedrick CC

Journal of Immunology 2015 195(5):2157–2167

Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense

Verma S, Loewendorf A, Wang Q, McDonald B, Redwood A, Benedict CA

PLoS Pathogens 2014 10(8):e1004268